Metabolic disorders (such as inherited metabolic disorders and mitochondrial disorders).Endocrine disorders (such as diabetes mellitus).Blood disorders (such as sickle cell disease).Heart disease (such as congenital heart disease, congestive heart failure and coronary artery disease).Chronic lung disease (such as chronic obstructive pulmonary disease and cystic fibrosis).Neurological and neurodevelopmental conditions.People who have medical conditions including:.Last flu season, American Indians and Alaskan Natives seemed to be at higher risk of flu complications.Children younger than 5, but especially children younger than 2 years old.Groups at Increased Risk of Severe Influenza The annual impact of seasonal influenza in the US: Measuring disease burden and costs. Molinari NM, Ortega-Sanchez, IR, Messonnier ML, et al. Influenza-associated hospitalizations in the United States. Thompson WW, Shay DK, Weintraub E, et al. Estimates of deaths associated with seasonal influenza - United States, 1976-2007. Influenza results in substantial economic impact – estimated at ~$37.5 billion 4ġ-2.Annual average of 220,000 hospitalizations – about 50% in 65 and older 3.About 90% of deaths occur among people 65 years of age and older 2.Annual estimated flu-associated deaths from 1976-2007 ranged from a low of about 3,000 deaths (1986-1987 season) to nearly 49,000 deaths (2003-2004 season) 1.Difficult to predict severity or timing.Flu seasons vary substantially from year to year.What is the Impact of Seasonal Influenza in the United States? Children, severely ill persons, and those with weakened immune systems may shed virus for longer than 7 days.Most people will shed virus and possibly able to spread flu to others for 5-7 days after illness onset.This means that people can be contagious to others from the day before illness.Viral shedding can begin 1 day before illness onset.Less often, a person might also get flu by touching a surface or object that has flu virus on it and then touching their own mouth or nose (contact transmission).(large droplet transmission, small particle droplet nuclei) These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs.Most experts think that flu viruses are spread mainly by droplets made when people with flu cough, sneeze or talk. ![]()
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